Solid-phase chemoenzymatic synthesis of C-sialosides.
نویسندگان
چکیده
The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 69 20 شماره
صفحات -
تاریخ انتشار 2004